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doi: 10.1161/CIRCULATIONAHA.124.068244

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Finally, to assess any potential safety issues, we conducted preliminary safety studies in TBI mice and in healthy rats

elegans models suggested MitoQ did not reduce mtDNA oxidative lesions directly, more recent reviews confirm that MitoQ enhances mitochondrial antioxidant defenses, reduces mtROS, suppresses inflammasome activation, and promotes anti-inflammatory microglial polarization, all contributing to reduced mtDNA damage and dampened inflammatory signaling [159]