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Los anlogos de B12 son estructuras corrinoides que contienen cobalto pero no tienen la actividad de la vitamina, ya que tienen alteraciones en el ncleo corrnico

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Subsequently, German internist Arnold Cahn (1858-1927) and German physician and physiologist Josef Freiher von Mering (1849-1908), working in the Strassburg clinic of German physician Adolf Kubmaul (1822-1902), showed that a patient with pernicious anemia had no hydrochloric acid in the stomach contents, a finding later demonstrated to be pervasive in this disorder and to precede the development of anemia (139)