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This may be attributed to the role of metformin in reducing the production of sFlt-1 and soluble endoglin by endothelial cells, trophoblasts, and syncytiotrophoblasts, and modulating anti-angiogenic factors at the mitochondrial level (Romero et al., 2017)
Nora, E

doi: 10.3390/cancers12010138

[DOI] [PubMed] [Google Scholar] 12.Lauer A.A., Grimm H.S., Apel B., Golobrodska N., Kruse L., Ratanski E., Schulten N., Schwarze L., Slawik T., Sperlich S., et al