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The basic strategy is to obtain a reagent focusing its activity prevalently around the cells expressing CD38, which enables avidity-induced blocking of CD47 on the same cells, in this way avoiding unwanted off-tumor effects

Malhotra D, Saxena AK, Dar SA, Kumar V, Nasare N, Tripathi AK, Banerjee BD

This attenuation in osteoblast function disrupts the balance between bone formation and resorption, contributing to decreased bone mineral density

Now a days with more based on research data it is considered as more organic brain disease than systemic brain neurodegenerative disorder based on dysfunction of the neurotransmitter system of dopamine and iron signaling in brain with a unknown genetic mutation which modulate the metabolism of iron with different degree in brain and substantial space