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Intrathecally administered iron chelators (such as DFO) are expected to extensively chelate iron in the CSF and outer brain regions (such as cortex) and may eventually reach deeper brain regions via CSF circulation

Proal A, Marshall T

Therefore it is possible that zinc treatment leads to decreased enterocyte copper uptake through competition for uptake through ZIP4, although CTR1 is still likely to be the main copper transporter in this cell type based on knockout studies (Nose et al., 2006)

Many of these individuals experienced rapid symptom relief, often within minutes, and some reported prolonged improvement in overall well-being for weeks to months