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In conclusion, several nutrients can be considered to supplement the diet to prevent and/or ameliorate migraine through the improvement in brain energy production by the amendment of mitochondrial functions, and/or the decrease of oxidative stress (Figure 4)
A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis

Intracellular metabolite concentrations have to fine-tune the signaling networks governing metabolic pathways independently of the environment to ensure a balance between the availability of nutrients and the cellular capacity to use them effectively

As such, other mechanisms might exist
