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7 In these emergency situations, a single low dose of rasburicase (0.02 to 0.05mg/kg up to 3mg) can be administered and it is recommended that hemodialysis be readily available in the event of clinically significant hemolysis and acute renal failure

However, during aging, the interaction between fibroblasts and the ECM is disrupted by the fragmentation of collagen fibers

In an oxidative ER environment, activated ERO1 generates disulfide bonds by consuming O 2 in the presence of flavin cofactors, which are then passed to the protein for folding via PDI (Bosello-Travain et al., 2013

It occurs naturally in human plasma, saliva, and urine