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This inhibition of methylation leads to a reduction in the global 5mC content in the cell and decreases gene-specific hypermethylation at promoter CpG islands, which could lead to the reactivation of TSG inhibited by hypermethylation in cancer cells

Compared with the physiological pH environment, weak acidic culture conditions evoked a certain degree of reduction in cell activity in the T-AsiG-CPL group, emphasizing the sequentially responsive nanostrategy

[59] These findings were supported by another study on 50 patients of systemic sclerosis and with a mean follow-up of 3 years, which showed decreased attacks of Raynaud's phenomenon and fewer digital ulcers in the patients administered intravenous n-acetylcysteine

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