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This approach is best suited to: Adults 4065 with longevity-focused health goals who are already engaged in foundational health optimisation (sleep, nutrition, resistance training, metabolic health) Individuals with confirmed age-related decline in GH/IGF-1, with symptoms including reduced lean mass, increased visceral fat, impaired recovery, or sleep-quality deterioration Patients with chronically elevated inflammatory markers without acute disease Adults with disrupted circadian rhythm or age-related sleep degradation (Epitalon specifically addresses this) Those who have optimised foundational lifestyle variables and want an additional, evidence-informed intervention layer It is not appropriate as a standalone intervention for adults who have not addressed metabolic health, sleep, or body composition fundamentals

*Correspondence: Vinicius Gabriel Coutinho, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Threshold for Pre-existing Antibody Levels Limiting Transduction Efficiency of Systemic rAAV9 Gene Delivery: Relevance for Translation

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