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Although most of the NAPQI is formed in the liver, the kidney also metabolizes acetaminophen to the toxic metabolite and releases the cysteine conjugate into the bile as well as the blood for further elimination in urine

JAMA Neurol 71(5):634639 Grupke S, Hall J, Dobbs M, Bix GJ, Fraser JF (2015) Understanding history, and not repeating it

E7 inactivates the retinoblastoma protein, while E6 inactivates p53

Establishing unified and standardized OA animal models, local administration protocols, and comprehensive efficacy evaluation systems will be key to promoting the translation of ferroptosis-targeted therapies from the laboratory to the clinic