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Drugs with molecular weights less than 300 Da easily cross the nasal epithelium and are rapidly absorbed, irrespective of their lipophilicity
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Furthermore, the diffusion coefficient can be used to calculate the hydrodynamic (Stokes) radius R h (or R S , which is the radius of the equivalent hydrodynamic sphere) of a protein using the Stokes-Einstein equation relating the diffusion of a spherical particle in a fluid to its size and the properties of the fluid
