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Although the exact mechanism of action for quinine sulfates effectiveness for the treatment of muscle cramps in patients with cirrhosis is elusive, it has been proposed that it reduces the excitability of the motor nerve by prolonging the refractory period of muscle to repetitive stimuli

Clearly an adventuress who was excited by the wild, uncharted aspect of the islands, she wrote, 'They were practically unknown no other English people had then travelled through the archipelago.' Intrepid as only those Victorian lady explorers could be, she had set out, notebook in hand, determined to describe her journey - by boat, on foot, camel, donkey and horse - through all seven islands

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