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inject slowly and steadily [12]
[14] In severe or inherited forms of biotin deficiency (such as biotinidase deficiency), even higher daily doses may be employed, and lifelong supplementation can be necessary under medical guidance
The transition from observing natural NPY as a biomarker to using exogenous NPY as a treatment involves assumptions about dose-response relationships that have not been fully validated in human trials
All primers used were listed in Supplemental Table 2
