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Both inducers lead to rapid induction of MT mRNA, but while the response to metal is biphasic and the level of the mRNA declines after prolonged exposure, the response to the hormone is persistent and once a new elevated steady state level of MT mRNA is achieved, it is maintained as long as the hormone is present heavy metal induction is mediated through the removal of a repressor of MT gene expression
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RPE cells rely on mitochondria for energy production, performing oxidative phosphorylation and reductive carboxylation, a unique form of mitochondrial energy production that produces TCA cycle intermediates during hypoxic conditions [58,59,60]
Body fatness and cancer viewpoint of the IARC working group
