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Observations that rats treated with CsA develop hypertension prior to myocardial hypertrophy (4, 101, 153155) supported the notion that perhaps the clinical hypertrophic phenotype is purely related to CNI-induced hypertension rather than direct myocardial effects

However, new studies of liver regeneration, hepatocarcinogenesis, liver transplantation, and various cell lines show that a variety of cell types participate in maintaining hepatocyte number and mass

Shaking can cause foaming, which indicates that the peptide chains are breaking and the compound is losing its efficacy for your metabolic assays

We are also thankful to BioRender (biorender.com) for the resources used to create the figures in the manuscript