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In patients with sepsis, supplementation in the early phase improved clinical parameters and mitochondrial dysfunction (55)

Interestingly, one recent study showed that small extracellular vesicles (sEVs) released from adipocytes in response to an artificial mitochondrial stress can activate a protective pathway in cardiomyocytes, exemplifying inter-organ mitohormesis in mammalian systems (Crewe et al, 2021)