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The 1298C/677T (compound heterozygous) and 677TT MTHFR variants in order pose escalating bottlenecks, 35% and 70% respectively, in recycling Hcy to methionine (Frosst et al., 1995)
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An advanced comprehension of the basic biology of CHAC enzymes, derived from rigorous biochemical and genetic studies, is therefore a prerequisite for their rational therapeutic exploitation
Neurology - Neuroimmunology Neuroinflammation 7 (3):e696 Walikonis JE, Lennon VA
