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The cytotoxicity of hydrogen peroxide primarily occurs through its ability to generate hydroxyl radical through metal-catalyzed reactions, such as the Fenton reaction (reaction 2) In biology it seems likely that this reaction is particularly important as part of the Haber-Weiss reaction, where iron (or copper) is maintained in a reduced form by superoxide and hence capable of catalyzing the formation of the hydroxyl radical from hydrogen peroxide (134)

Potential interactions between polyphenols and common drugs used in cisplatin combination chemotherapy also need to be noted

Blanford C

, Gross J., Wollbrink A., Fellmeth R., and Baune B