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Oral supplementation has shown effectiveness but may not match the efficacy of IM in certain scenarios

Two independent mechanisms = a potentially synergistic combination

The standard AOD 9604 dosage in clinical use is 250500 mcg, administered subcutaneously once every morning on an empty stomach, and cycled in 412-week blocks

(8) Research has demonstrated that SAM is a universal methyl donor required for numerous cellular methylation reactions including DNA and histone methylation
