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In this review, we highlight insights from recent unbiased phosphoproteomics studies, which have enabled a comprehensive examination of insulin signalling and have transformed our perspective on how signalling changes may contribute to insulin resistance

Emerging evidence demonstrates that the dynamic modification of histones through methylation/demethylation can link metabolism with transcription, acting as molecular transducers of metabolic signals to chromatin

Most of the affected structureshippocampus, amygdala, frontal cortex, and anterior cingulate cortexare known to play a role in emotional regulation and cognition