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Targeting mitochondrial oxidative stress and dysfunction for AILI treatment In the injury process of APAP hepatotoxicity, mitochondrial proteins are the main targets of NAPQI, compared with total protein-binding in hepatocytes, including housekeeping protein, glutathione peroxidase (GPx) and adenosine triphosphate (ATP) synthase -subunit [95]

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In zebrafish, the administration of ALD has been demonstrated to reduce SREBP-1c and FASN, thereby enhancing energy metabolism and mitigating injury (Park and Kim 2020)

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