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Absorption Pathway Analysis The nasal spray formulation itself is being studied for its potential to support alternative absorption pathways in research environments

23,24 Consider and treat precipitating factors of drowning: trauma, spinal cord injury, seizure, MI, arrhythmia, toxin, syncope or hypoglycemia Monitor for sepsis, disseminated intravascular coagulation (DIC), and renal insufficiency/failure CT head & neck: edema or loss of gray-white matter distinction strongly predicts poor outcome, but normal CT is of little prognostic value POST-CPR CARE: consider 12-24 hours of therapeutic hypothermia in patients with return of spontaneous circulation (ROSC) to improve neurological outcomes similar to cardiac arrest Drowning victims with ROSC who remain comatose should NOT be actively rewarmed above 90-93F/32-34C Drowning victims with ROSC whose core temperature is 93F/34C should be cooled to 90-93F/32-34C as soon as possible Cerebral O2 consumption decreases 5% for each reduction of 1C within the range 37-20C Pulmonary Considerations Hypoxemia decreased levels of oxygen in the blood

They are not approved for human or veterinary use, and no dosing guidance is provided.