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Research findings on glucose homeostasis [6] : Oral glucose tolerance testing showed no negative impact on glucose levels in human subjects No insulin sensitivity changes following chronic exposure Fat-reducing effects occur without inducing insulin resistance Avoids common metabolic complications associated with hGH therapy This metabolic selectivity positions the peptide as targeting adipose tissue lipid metabolism without broader endocrine disruption affecting growth, glucose regulation, or protein synthesis

Pouliot MC, Desprs JP, Nadeau A, Moorjani S, PrudHomme D, Lupien PJ, Tremblay A, Bouchard C

When NNMT is active, it methylates nicotinamide (a form of vitamin B3), making it unavailable for conversion into NAD a crucial molecule for energy production and cellular repair