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Rare but serious adverse events, such as severe hepatotoxicity, pancreatitis, or moodrelated changes, necessitate prompt evaluation and discontinuation of therapy when identified

However, a blanket recommendation has not been made in clinical guidelines as there are needs for stronger evidence and determinations of effective doses and specific patient populations that might benefit (Varadharaj et al., 2017)

Regarding OVCAR3 cells, no differences were found in total cell death levels in both time-points (Fig

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