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PSEN1/2 mutations identified in Alzheimer patients affected the hypoxic response in mouse embryonic fibroblasts by regulating hypoxia inducible factor-1 (HIF-1), a driver of vulnerability to ferroptosis in cancer (Kaufmann et al., 2013

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and B.E.I., and DFG CO 1305/2-1 to M.M.C.-K), to the Forschungskommission of the Universittsklinikum Dsseldorf (to M.M.C.-K.) and the Susanne-Bunnenberg-Stiftung of the Dsseldorf Heart Center (to M.K.), National Institutes of Health (USA) HL0088554 (to B.E.I.), and American Heart Association Grant #16PRE31180040 (to T.C.S.K.) for financial support