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In particular, p53 regulates both the mitochondrial transcription machinery, by translocating to mitochondria and activating TFAM (Lopez-Otin et al., 2013), and mitochondrial respiration, by interfering in the balance between glycolytic and oxidative pathways (Fiorenza et al., 2018)
Orienting in a defensive world: mammalian modifications of our evolutionary heritage
This shows we need good treatments, like ear infection drops and ear pain medicine for adults