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In the research that exists, GHK-Cu has a reassuring safety profile: it occurs naturally in the body, is active at tiny (nanomolar) amounts, and has been used in topical cosmetics for decades without notable problems.[2] That track record, though, is mostly about topical use the safety of injected GHK-Cu has not been established in controlled human trials, and it's not an approved drug
In addition, encephalopathy or delirium may develop relatively slowly and result in dementia

The extracellular matrix environment is another major variable

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