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doi: 10.1016/j.envres.2011.01.013

While the exact trigger varies, common causes include sudden emotional or physical stress, which can trigger an autoimmune response in which the body mistakenly attacks its own melanocytes

Once in use , keep the pen at a room temperature of less than 30 C, or it can remain in the fridge in the same conditions as before opening

228 Glucocorticoids such as prednisolone (Prednisone) are sometimes used to treat men with infertility expressing antisperm antibodies
