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The primary signal of this retrograde signaling is ROS

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This research received funding from the Changzhou Sci-Tech Program Applied Basic Research General Project (CJ20245013, Tongbin Chen), Changzhou Medical Center of Nanjing Medical University Basic Research Program (CMCB202417, Xi Chen) and Top Talent of Changzhou The 14th Five-Year Plan High-Level Health Talents Training Project (2024CZBJ011, Xi Chen) and 2022 Annual Youth Talent Science Project of the Health Commission of Changzhou City (QN202217, Wenyue Da)

Thus, multiple downstream mechanisms may underlie the antidepressant activity of ascorbic acid