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Despite this early promise, however, attempts to expand the use of combined immune checkpoint blockade and radiotherapy beyond the consolidation setting have had mixed results [113,114,115,116,117]

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Using this invasive technique, intra-arterial infusion of lipoic acid was found to improve endothelium-dependent vasodilation in 39 subjects with type 2 diabetes but not in 11 healthy controls (62)

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Trial REDEFINE 3 (ongoing) Phase 3 Duration Event-driven Population (N) Adults with cardiovascular disease Key Result Cardiovascular outcomes readout pending

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Furthermore, a synergistic oral mixture of hesperidin, a type of citrus bioflavonoid, and rosemary for 12 weeks significantly increased the MED after UV irradiation at 8 and 12 weeks compared to placebo (51)

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