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Description
The neuroprotective mechanisms identified - reduction of oxidative stress, modulation of inflammatory cytokines, enhancement of nerve growth factor - are theoretically sound

ONS-76 is sensitive to SMO inhibitors, and unlike DAOY, rarely develops GLI2-driven resistance, likely due to functional TP53

Shin J-H, Ko HS, Kang H et al (2011) PARIS (ZNF746) repression of PGC-1 contributes to neurodegeneration in Parkinsons disease

J., Kalra, P
