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Funding: This work was supported by the National High Technology Research and Development Program of China (Project 2006AA02Z4B5), National Natural Science Foundation of China (Projects 81070033, 30770835, 81170608, 81072091)

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Morbilliform rash, eschar, splenomegaly, and lymphadenopathies are typical signs

Analytical methods, chromatographic and mass spectrometric conditions Chromatographic and mass spectrometric conditions on the HPLC/MS/MS system were used as described before 34 with some slight modifications