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(October 2005)

Discussion Here we demonstrate here that selectively targeting the CD38 NADase ectoenzyme with the catalytically inhibitory heavy-chain monoclonal antibody can mitigate skin and lung fibrosis in mice

Structural focus: As a 16-amino acid peptide, this research compound is significantly smaller and more structurally defined than the 191-amino acid full GH molecule, making it a more tractable research tool for studying specific receptor-ligand interactions and downstream signalling mechanisms in controlled laboratory settings

Unlike a long-acting compound that commits a subject to a week-long effect, the short 5-Amino-1MQ half life allows for more dynamic adjustments to the protocol