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Depletion of tryptophan (a Candida metabolic substrate) reduces serotonin synthesis, while chronic gut inflammation elevates inflammatory cytokines (IL-6, TNF-) that independently suppress mood via neuroinflammatory pathways

doi: 10.1016/s0014-5793(98)00281-6

2 A fragment reproducing only a slice of that signaling may produce a real but modest lipolytic nudge enough to register as a statistically significant reduction in weight gain in a growing obese rodent, but too small to drive meaningful weight loss in a weight-stable human adult already dieting and exercising

In contrast, mutation of C79 did not protect against GSSG-mediated inactivation (Fig