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854 Changes associated with ferroptosis in the cartilage of the injured articular area in OA patients, including GPX4 downregulation, ACSL4 upregulation, MDA accumulation, and mitochondrial morphological and function changes, are more severe than in the intact articular area and worsen with OA progression

Rather, enzyme kinetic analyses and experiments where the addition of an alternative CoQH 2 oxidase (AOX) to bovine heart mitochondrial membranes caused a substantial increase of the electron flux through the CI/CIII 2 /CIV suggest that there is no sealed-in CoQ pool in SCs (64, 65)