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[DOI] [PubMed] [Google Scholar] 108.Yamada K, Wada E, Santo-Yamada Y, Wada K

If human trials reveal minimal systemic absorption after oral dosing, the peptide's utility for GERD would be limited to topical esophageal application or parenteral routes, both of which present practical barriers for chronic reflux management

Especially back then

Nat Rev Gastroenterol Hepatol
