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To articulate the matter differently: exosome possession of inherent advantages facilitates their efficient delivery of proteins and genes to target cells (140), thereby contributing to a variety of biological processes (141)

For example, in particulate matter exposure-related models, GLS1-mediated enhancement of glutaminolysis, together with alterations in local Gln/-KG levels, can be accompanied by enhanced M1-like polarization, and inhibition of GLS1 can alleviate this pro-inflammatory polarization trend ( Overall, in addition to serving as a carbon skeleton source to replenish the TCA cycle, Gln metabolism supports TCA cycle anaplerosis and OXPHOS while providing key intermediates such as -KG, thereby participating in metabolism-epigenetic coupling and influencing the positioning of macrophages along the pro-inflammatory to reparative functional spectrum ( 4.4 Branched-chain amino acids Branched-chain amino acids (BCAAs

Long-term use of certain medications such as metformin and proton pump inhibitors (PPIs) also increases the risk of B12 deficiency

Eur Endocrinol 12(2):96 Stancioiu F, Mihai D, Papadakis GZ, Tsatsakis A, Spandidos DA, Badiu C (2019) Treatment for benign thyroid nodules with a combination of natural extracts