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IR leads to hepatic lipid metabolism disorders, particularly affecting fatty acid -oxidation, DNL and VLDL synthesis [73]

2 3 These enzymes play key roles in the oxidation of alcohol, affecting the rate of alcohol clearance in the body and the generation of its metabolites

Women classified with severe (rASRM stage III and IV) endometriosis were particularly impacted, with a LBR of 1 and CLR of 5.1

8 The mechanisms of APAP-induced cell death, which apply to both animals and humans, include the formation of the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 2E1 (Cyp2E1), depletion of hepatic GSH, and protein adduct formation, primarily in mitochondria