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His owners were unsure whether he was itchy or overgrooming
After 1824 h of PFOS treatment, a significant induction of IRE1 and LC3BII was observed, whereas the p62 level was increased
A multidisciplinary expert statement
It was found that ORP4L transported PLC-3 out of the nucleus of leukemia cells, and regulated PIP2 metabolism and downstream Ca 2+ balance by forming ORP4L/Gq/11/PLC-3 complex, further regulating pyruvate dehydrogenase activity on mitochondria to provide oxidative phosphorylation energy for leukemia cells
