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In particular, low Treg numbers or Treg dysfunction aggravates autoimmune activity and results in SLE development

van Gerwen J, Amber S-SS, Fazakerley DJ

El-Wetidy MS, Rady MI, Rady I, Helal H

In the process of development, there will be renal tubular atrophy, glomerular sclerosis, and microvascular sparse, forming a vicious circle and finally, the kidney completely loses its organ function [148]
