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[DOI] [PMC free article] [PubMed] [Google Scholar] 256.Matsushita M, Freigang S, Schneider C, Conrad M, Bornkamm GW, Kopf M

NO-mediated activation of soluble guanylate cyclase (sGC) stimulates synthesis of cyclic GMP (cGMP), which in turn binds to and activates protein kinase G (PKG)

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Thus, when subjected to oxidative stress, the destruction of red blood cells occurs more quickly than normal.[ref] While most people have no day-to-day symptoms from this disorder, hemolytic anemia can occur more easily in people with G6PD deficiency