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It is rarely possible to do all five at once, and each child needs the protocol adapted to their unique presentation, but the order matters

Some research protocols start at 2mg daily for the first week before increasing to the target dose

Lastly, astrocytes play an important role in neurovascular coupling, connecting neurons and the vasculature [110]

Patient families expressed the following: Long-term goal is independenceFunctional independence and personal autonomy are key outcomes with the greatest impact for improving quality of life Incremental therapiesFirst slow, then halt, disease progression, then work to reverse symptoms Sustainable therapiesLifelong diseases need lifelong treatments, therefore the therapies we identify must be available to patients for as many years as they need, and have a minimized financial burden II