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Naunyn Schmiedebergs Arch Pharmacol 391:12471255 Shalkami A-GS, Hassanein EH, Sayed AM, Mohamed WR, Khalaf MM, Hemeida RA (2021) Hepatoprotective effects of phytochemicals berberine and umbelliferone against methotrexate-induced hepatic intoxication: experimental studies and in silico evidence