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In addition to de novo biogenesis, lysosomes can be generated through autophagic reformation
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APOE4 carriers exhibit heightened neuroinflammation under hypercholesterolemic conditions due to impaired cholesterol efflux (232), highlighting genetic susceptibility to chronic microglial activation
doi: 10.2174/157015908783769671 103 McAllisterJGhoshSBerryDParkMSadeghiSWangKXet al
