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Excessive methyl supplementation taking too much methylfolate or methyl-B12 for your needs COMT mutations slow breakdown of neurotransmitters, causing buildup when you add more methyls Histamine issues methylation can increase histamine in some people

But a new legal analysis published April 21, 2026 argues the story is more complicated: the FDA is taking procedural steps that could lead to legal compounding access under Section 503A, but it has not (yet) made these peptides legal to compound as bulk substances

The delayed gastric emptying means food sits in your stomach longer, creating physical distension

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