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3.5 Parallel defense pathways: GPX4, DHODH, and FSP1 Although the GPX4GSH axis is widely recognized as the primary defense line against plasma membrane lipid peroxidation and ferroptosis, recent discoveries have identified GPX4-independent parallel defense mechanisms within cells, revealing the complexity and redundancy of the cellular antioxidant network

Wang X, Winter D, Ashrafi G, Schlehe J, Wong YL, Selkoe D, Rice S, Steen J, LaVoie MJ, Schwarz TL

Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans

2008) and gained considerable interest as modulators of family CGprotein coupled receptors (Wang et al