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In order that these findings may reach as wide a readership as possible, we are placing this brief but important report under the heading Generalia

Increasing FSH levels during the late luteal phase leads to an increase in the number of FSH receptors and ultimately to an increase in estradiol secretion by granulosa cells

Genotyping selected groups of individuals at risk for adverse events may allow possible reintroduction of affected drugs that were withdrawn at one time by regulators because of rare but serious adverse events

Effective pain prevention and management, therefore, require not only treating the biological consequences of these environmental factors but also, where possible, mitigating their occurrence through improved surgical techniques, ergonomic interventions, and public health policies aimed at reducing broader environmental stressors