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Under high glucose conditions, Rho A is activated, leading to elevated intracellular oxidative stress, increased release of inflammatory cytokines (e.g., TNF- and IL-1) from renal tubular epithelial cells, and changes in the expression of fibronectin, CTGF, TGF-1, collagen type IV, and E-calcineurin, which regulate calponin-mediated cell-cell adhesion, as well as increased pro-fibrotic growth factor, and expression of extracellular matrix components and extracellular matrix components

Nat Rev Endocrinol (2010) 6(7):38095

Glutathione is synthesized from L-glutamate, L-cysteine, and glycine in a two-step process that uses 11%12% of lens ATP

Yepiskoposyan, J