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Oxidative stress and cellular response to doxorubicin: a common factor in the complex milieu of anthracycline cardiotoxicity
Similarly, circLMO1 downregulates miR-4291, resulting in elevated ACSL4 levels that induce ferroptosis in cervical cancer (Ou et al., 2022)
Another potent oral PARP1/2 inhibitor, niraparib (MK4827) binds to the active site of PARP enzymes, and studies indicate that Niraparib can restore NAD + levels and improve mitochondrial function 165,166
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