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Abstract Lead is one of the most common heavy metal elements and has high biological toxicity

Currently, there is a significant gap in such studies for these combinations, which hinders the optimization of dosing regimens, prediction of drug interactions, and understanding synergistic or antagonist effects of the agents

Pyroptosis The canonical pathway of pyroptotic cell death requires the priming and assembly of multiple signals, triggered by multiple DAMPs and PAMPs through TLRs

however, such findings are not uncommon in patients with bronchopulmonary disease and a causal relationship has not been established
